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KMID : 0615720100270050013
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Jouranl of Korean Acupuncture and Moxibustion society
2010 Volume.27 No. 5 p.13 ~ p.24
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Effects of Bee Venom Acopuncture at Sinsu(BL23) and Daejangsu(BL25) in Different Concentration on Neuropathic Pain Induced by Tibial and Sural Nerve Injury in Rats
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Chiang Suo-Yue
Bang Sung-Pil
Kim Jae-Hong
Wei Tung-Sheun
Yoon Yeo-Choong
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Abstract
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Objective:This study was designed to investigate the effects of bee venom acupuncture at Shinsu(BL23) and Daejangsu(BL25) on neuropathic pain induced by tibial and sural nerve injury in rats.
Methods:Neuropathic pain model was made by partial resection of tibial and sural nerve. Three weeks after the neuropathic surgery, bee venom acupuncture was firstly injected at BL23 and BL25, then we measured withdrawal responses induced by von Frey filament and acetone stimulation. Bee venom acupunctures were injected 6times on every 2days. Measurement of withdrawal responses were conducted on the same days. After bee venom acupuncture injection, expression levels of c-Fos, nocieptin and KOR-3 were observed through using immunohistochemistry.
Results:In this experiment, bee venom acupunctures at BL23 and BL25 decreased levels of withdrawal responses induced by von Frey filament and acetone stimulation respectively. In addtion, expression levels of c-Fos, nociceptin and KOR-3 in central gray part of brain in rats were decreased by bee venom acupuncture.
Conclusions:These results imply that bee venom acupuncture was useful to treat patients with neuropathic pain, and related mechanisms were involved in opioid and their receptors such as nociceptin and KOR-3.
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KEYWORD
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Bee venom acupuncture, Sinsu(BL23), Daejangsu(BL25), c-Fos, Nociceptin, KOR-3
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